A very useful series of lecture slides on brain physics (and physiology) that covers many relevant topics. Published online by Cambridge University, Division of Neurosurgery, Department of Clinical Neurosciences.
Cerebral Physiology An excellent article from 2013 that provides a summary of the physiology of cerebral circulation and metabolism. By Alifia Tameem MBBS MD FRCA Hari Krovvidi MD FRCA for Continuing Education in Anaesthesia, Critical Care & Pain.
Neurogenic Pulmonary Oedema by Dr John Griffiths of Anaesthesia UK. A very nice synopsis of this very relevant topic.
Published in 2013 this Cochrane Review of the Lund Concept for Severe Traumatic Brain Injury by Muzevic and Splavski could not find any high-grade evidence to support the practice associated with this concept. “There was no evidence from randomised controlled trials on the effe cts of the Lund concept in the management of severe traumatic brain injury. This treatment should not… Continue reading Cochrane Review – The Lund concept for severe traumatic brain injury
In the reviewers own words: “This review covers the main principles of the Lund concept for treatment of severe traumatic brain injury. This is followed by a description of results of clinical studies in which this therapy or a modified version of the therapy has been used.” Published 2014 in Neuroscience by Koskinen et al. Access the abstract here. This… Continue reading Review – Severe traumatic brain injury management and clinical outcome using the Lund concept
Published in 2013, the joint CNS/AANS Guidelines for the first time discourage the use of steroids for traumatic spinal cord injury. This comes after a thorough review of existing evidence and a critical re-examination of the NASCIS-studies previously interpreted as favouring steroid use. “In summary, there is no consistent or compelling medical evidence of any… Continue reading Steroids and Spinal Cord Injury – Excerpts From the Joint CNS/AANS Guideline
Spinal cord injury guidelines issued jointly by the Congress of Neurological Surgeons (CNS) and the American Association of Neurological Surgeons (AANS). Published in Neurosurgery 2013. Read the full guidelines here.
The most updated review by the Cochrane Collaboration on steroid use and traumatic brain injury. The vast majority of patients stem from the CRASH trial. “In the absence of a meta-analysis, we feel most weight should be placed on the result of the largest trial. The increase in mortality with steroids in this trial suggest… Continue reading Cochrane Review – Steroids and TBI
Well known and must-read paper on the use of steroid cover in TBI patients. It is by far the largest trial on this subject and still forms the basis for today’s recommendations that steroids not be used in this patient group. Published in the Lancet 2005. “The risk of death was higher in the corticosteroid… Continue reading CRASH Trial on Steroids and TBI
ProTECT III, the results of which were published alongside those of the SYNAPSE-trial in the December 25 2014 issue of NEJM, demonstrates no patient-important advantage conferred by the administration of progesterone (albeit very early in this particular study) to TBI patients. “This clinical trial did not show a benefit of progesterone over placebo in the… Continue reading ProTECT III -Progesterone in TBI, Another Step Towards Futility
neuroscand.com 