Neuroprotection · Progesterone · TBI General

ProTECT III -Progesterone in TBI, Another Step Towards Futility

ProTECT III, the results of which were published alongside those of the SYNAPSE-trial in the December 25 2014 issue of NEJM, demonstrates no patient-important advantage conferred by the administration of progesterone (albeit very early in this particular study) to TBI patients. “This clinical trial did not show a benefit of progesterone over placebo in the… Continue reading ProTECT III -Progesterone in TBI, Another Step Towards Futility

Neuroprotection · Progesterone · TBI General

Progesterone in TBI, Results from the SYNAPSE-trial

A Clinical Trial of Progesterone for Severe Traumatic Brain Injury, by¬†Brett E. Skolnick et al, 2014. New England Journal of Medicine. “Primary and secondary efficacy analyses showed no clinical benefit of progesterone in patients with severe TBI. These data stand in contrast to the robust preclinical data and results of early single-center trials that provided… Continue reading Progesterone in TBI, Results from the SYNAPSE-trial