Just a quick update on two recent trials on pharmacological treatment for status epileptics in children: Both articles were published in the Lancet this spring. ConSEPT and EcLiPSE, both high-quality trials, found levetiracetam and phenytoin to be equally effective in seizure control and similar in safety profile. The findings were be remarkably consistent across the… Continue reading ConSEPT and EcLiPSE Trials: Levetiracetam Equal to Phenytoin in Efficacy for Convulsive Status Epilepticus in Children
From our quality-focused colleagues at the Society for Neuroscience in Anesthesiology and Critical Care (SNACC) comes this set of guidelines for management of the most common emergencies encountered in neuroanaesthetic practice. Conceived with the purpose of addressing complex emergent issues in a concise, goal-directed and simplified manner, these cognitive aids are clear-cut and based on… Continue reading SNACC – How to Handle Neuroanaesthetic Emergencies
Excellent and widely read overview of sedation regimes in acute brain injury. Find the article by Oddo et al in Critical Care here.
Results from the HYBERNATUS trial were just published in the New England Journal of Medicine by Legriel et al. This study recruited 270 patients with convulsive status epilepticus, randomized to either therapeutic hypothermia (32-34 C) or normothermia. All patients were intubated and on controlled ventilation when included. All received standard antiepileptic pharmacological treatment. Primary outcome… Continue reading HYBERNATUS Trial: Hypothermia Not Associated With Better Outcomes in Status Epilepticus
Recently released Podcast by HEFT -EMCast (Heart of England Foundation Trust’s Emergency Department) on status epilepticus. Latest evidence digested and made clinically useful. Special emphasis on early and aggressive treatment for those patients who don´t seem likely to recover after initial first-line management. Largely based on the NICE guidelines from 2012.
Refractory Status Epilepticus: Epidemiology, Clinical Aspects and Management of a Persistent Epileptic Storm. Excellent article by Sutter et al. 2012. Published in Epileptologie in English, German and French. Sutter_Ruegg_19.11.12
Excellent review arcticle from 2011 by Shorvon et al on the subject of intractable status epilepticus. Published in Brain.