Category: Neuroprotection

Neurocritical Care · Neuromonitoring · Neuroprotection · Neurotrauma · Traumatic Brain Injury

Lung Injury Is a Predictor of Cerebral Hypoxia and Mortality in Traumatic Brain Injury – Retrospective Study

andersfeylingLeave a comment

This recently published open-access article by Robba et al delves into the retrospective monitoring data on 70 TBI patients. The patients in the cohort were all monitored comprehensively, providing the investigators with continuous data on PbtO2, ICP and CPP, as well as on relevant respiratory indices. They found a statistically significant link between lung function… Continue reading Lung Injury Is a Predictor of Cerebral Hypoxia and Mortality in Traumatic Brain Injury – Retrospective Study

Cervical Spine Injury · Neuroprotection · Neurotrauma · Scandinavian Guidelines · Thoracolumbar Spine Injury

New Danish Guidelines on Spinal Stabilisation in Trauma

andersfeylingLeave a comment

Our Danish colleagues have recently issued updated guidelines on spinal stabilisation of adult trauma patients (open-access in the Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine). As expected, the evidence base is fairly limited as robust randomised studies on this topic are rare and often hard to conduct. The group does provide a strong recommendation… Continue reading New Danish Guidelines on Spinal Stabilisation in Trauma

Acute Cerebrovascular Conditions · Ischaemic Stroke · Neuroprotection · Thermoregulation

Addition of hypothermia to decompressive hemicraniectomy is not useful in MCA stroke – JAMA

riikkatakalaLeave a comment

This study, recently published in JAMA, revealed no beneficial effect from hypothermia as an adjunct to decompressive hemicraniectomy in the setting of middle cerebral artery stroke. In fact, the authors’ findings even suggest harm. Find the article here.

Neurocritical Care · Neuroprotection · Neurotrauma · Traumatic Brain Injury

Glycaemic Control Targets After Traumatic Brain Injury: A Systematic Review and Meta-analysis

andersfeylingLeave a comment

Hermanides and colleagues recently reviewed all available evidence on blood glucose targets in the TBI patient. Read their finding in this article in Critical Care. When comparing strict glycaemic regimens with more liberal strategies they found no significant differences in patient-important outcomes, contrary to earlier findings. They did reveal an increased risk of hypoglycaemia, however.… Continue reading Glycaemic Control Targets After Traumatic Brain Injury: A Systematic Review and Meta-analysis

ICP/CPP management · Neurocritical Care · Neuroprotection · Neurotrauma · Thermoregulation · Traumatic Brain Injury

POLAR RCT – Don’t Worry, Thermoregulation Isn’t Dead Quite Yet

andersfeylingLeave a comment

POLAR RCT is probably the most anticipated neurotrauma trial of the year and its findings were finally presented at this year’s ESICM congress in Paris. Before I comment on what POLAR RCT is all about, it’s worth taking some time to consider what this trial is NOT about. It does not deal specifically with TBI… Continue reading POLAR RCT – Don’t Worry, Thermoregulation Isn’t Dead Quite Yet

Acute Cerebrovascular Conditions · Basic Sciences & Physiology · Neurocritical Care · Neuromonitoring · Neuroprotection

Lactate Improves Cerebral Perfusion After Acute Brain Injury – Recent Clinical Trial in Crit Care Med

andersfeylingLeave a comment

Lactate is well-known as an important energy substrate for brain tissue and plays a key role in neuroenergetics. Experimental data have shown that exogenous lactate administration may improve metabolism in injured brain cells, and possibly has neuroprotective properties. Till now there has been a paucity of human clinical studies on this subject. Carteron et al… Continue reading Lactate Improves Cerebral Perfusion After Acute Brain Injury – Recent Clinical Trial in Crit Care Med

Basic Sciences & Physiology · Fluid Management · General Topics · Neurocritical Care · Neuroprotection · Osmotherapy

Hyponatraemia and the Brain – Review

andersfeylingLeave a comment

I came across this useful little review in Kidney International Reports covering a subject I always find difficult to grasp: sodium disturbances and their influence on the brain. The article delves into the matter in a concise and understandable way, making it just about  manageable even for an anaesthetist.

Neurocritical Care · Neuroprotection · Neurotrauma · Traumatic Brain Injury

Lancet Neurology – Special Issue Dedicated to TBI

andersfeylingLeave a comment

I realise that this is old news by now, but I´ve somehow neglected to put out this excellent collection of articles on NeuroScand. The November issue of Lancet Neurology is dedicated in its entirety to traumatic brain injury and features a number of inspiring and thought-provoking editorials. Essential reading for the neurotrauma enthusiast.

Neurocritical Care · Neuroprotection · Thermoregulation · Traumatic Brain Injury

TTM – New Guidelines from NCS

andersfeylingLeave a comment

Targeted temperature management (TTM) as a neuroptotective strategy is applied in a number of scenarios; post-ROSC in cardiac arrest, neonatal asphyxia, traumatic brain injury, to name some. The Neurocritical Care Society have taken it upon themselves to formulate an evidence-based guideline to  the implementation and practical management of TTM in a number of settings. Although… Continue reading TTM – New Guidelines from NCS