Hypothermia · Neurocritical Care · Seizure Control

HYBERNATUS Trial: Hypothermia Not Associated With Better Outcomes in Status Epilepticus

Results from the HYBERNATUS trial were just published in the New England Journal of Medicine by Legriel et al. This study recruited 270 patients with convulsive status epilepticus, randomized to either therapeutic hypothermia (32-34 C) or normothermia. All patients were intubated and on controlled ventilation when included. All received standard antiepileptic pharmacological treatment. Primary outcome was GOS at 90 days; while among secondary outcomes were mortality at 90 days and progression to refractory and superrefractory SE. 

“In this trial, induced hypothermia added to standard care was not associated with significantly better 90-day outcomes than standard care alone in patients with convulsive status epilepticus.”

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