“There was no difference in the incidence of impairment between hypothermic and normothermic groups” Abstract: Effects of intraoperative hypothermia on neuropsychological outcomes after intracranial aneurysm surgery. Ann Neurol 2006. Anderson et al.
Free full-text via PubMed at: Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST) Investigators. Mild intraoperative hypothermia during surgery for intracranial aneurysm. Todd et al. NEJM 2005. “Intraoperative hypothermia did not improve the neurologic outcome after craniotomy among good-grade patients with aneurysmal subarachnoid haemorrhage”
This Cochrane Review by Saxena et al from 2014 reveals a paucity of RCTs to support moderate therapeutic hypothermia in TBI patients. It remains a widely used modality in spite of this absence of evidence. “In order to further explore the preliminary findings provided by animal models and observational clinical studies that suggests there may… Continue reading Cochrane Review – Modest cooling therapies (35ºC to 37.5ºC) for traumatic brain injury
Induced hypothermia and fever control for prevention and treatment of neurological injuries. Lancet. 2008, Polderman et al. http://www.ncbi.nlm.nih.gov/pubmed/18539227