Well written overview of ICP-management and the role of hyperosmolar therapy. By Ropper, 2014. The chapter comparing hypertonic saline and mannitol is particularly interesting.
“…treatment with mannitol may increase the likelihood of death when compared to treatment with hypertonic saline.” Read the Cochrane review from 2013: Mannitol for acute traumatic brain injury.
“.. infusion of 2 ml kg(-1) during 20 min has a predictable and clinically significant beneficial effect on ICP and CPP.” Predictable reduction of intracranial hypertension with hypertonic saline hydroxyethyl starch: a prospective clinical trial in critically ill patients with subarachnoid hemorrhage. Bentsen et al, Norway. Acta Anaesthesiologica Scandinavica, 2004 Oct. Read the abstract here. Hypertonic… Continue reading SAH-patients: HyperHaes and reduction in ICP (2004)
Review in Neurocrit Care. 2012. Torre-Healy et al. Hyperosmolar therapy for intracranial hypertension.